Work

Sporadic colorectal cancer: microbial contributors to disease prevention, development and therapy

Year: 2016

Type: review

Abstract: The gut microbiota has been hailed as an accessory organ, with functions critical to the host including dietary metabolic activities and assistance in the development of a proper functioning immune system. However, an aberrant microbiota (dysbiosis) may influence disease processes such as colorectal cancer. In this review, we discuss recent advances in our understanding of the contributions of the microbiota to prevention, initiation/progression, and treatment of colorectal cancer, with a major focus on biofilms and the antimicrobial and antitumoural immune response.

Source: British Journal of Cancer

DOI: 10.1038/bjc.2016.189

Authors: Julia L Drewes, Franck Housseau, Cynthia L Sears

Institutions: Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,190