As indicated by the diagram and as described by the data, it is possible that the crosstalk between the PI3K/AKT/GSK3β and ERK pathways is mediated in part by PKC
Year: 2011
Type: other
Abstract: Copyright information:Taken from "Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120"BMC Neuroscience 2005;6():8-8.Published online 2 Feb 2005PMCID:PMC549045.Copyright © 2005 Langford et al; licensee BioMed Central Ltd. PKC signalling also is reported to occur directly with PI3K and upstream of Ras. Furthermore, direct interaction between MEK and PKC downstream of Ras is reported. Likewise, ERK2 (p42) is reported to signal to Raf-1 via a positive feedback mechanism. The points of action of the inhibitors LY290042, U0126, Bisindolymaleimide I, and Gö6983 are also shown.
Source: Figshare
Authors: Langford, Dianne, Hurford, Rosemary, Hashimoto, Makoto, Digicaylioglu, Murat, Masliah, Eliezer
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6902261370