Changes in default mode network connectivity in the months following a motor vehicle collision
Year: 2013
Type: article
Study design: Observational Study
Abstract: This study investigates stress-related changes in the connectivity to the posterior cingulate cortex, the central node in the default mode network, in the survivors of Motor Vehicle Collisions (MVCs).Thirty-two subjects underwent Functional Magnetic Resonance Imaging (fMRI) resting-state scans two weeks following their MVCs.A subset of seventeen subjects completed an additional resting-state scan three months later.Stress symptoms were assessed with the Posttraumatic Stress Disorder Checklist (PCL) stressor version at each time point.Group difference analyses and correlation analyses between functional connectivity maps and PCL scores using SPM 5, fMRI analysis software, yielded significant results in the inferior parietal cortex/visual cortex, the hippocampi, the lateral temporal cortices, the anterior cingulate cortex, the amygdalae, and the dorsolateral prefrontal cortex.The results suggest that there was increased functional connectivity to limbic structures during the acute stress period when stress symptoms were high.This may reflect increased priming of those brain regions in response to acute stress.The connectivity decreased for subjects whose stress symptoms decreased three months later.Furthermore, correlations in the left inferior parietal
Author: Andrew S. Cotton
Institution: University of Toledo
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2472737743