Year: 2016
Type: conference-paper
Abstract: In the past few decades, a great interest has been focused on a naturally occurring class of polymers called chitosan for their large amount in nature, biodegradability and extensive applications.Water-soluble chitosan oligomer is composed of β-(1,4)-2-amido-2-deoxy-D-glucan and β-(1,4)-2-acetoamido-2deoxy-D-glucan(acetylglucosamine), and the low molecular weight substances obtained by acidic or enzymatic hydrolysis of chitosan.Until now, many researchers have examined chitosan oligomer as a promising material for biomedical applications on account of its good biocompatibility, biodegradability, antimicrobial activity and wound healing effects.Dye-labeled chitosan can be also employed in bio-imaging system, because it has low toxicity.Some dyes, such as Alexa Fluor, Cibacron Blue and fluorescein isothiocyanate (FITC), have been employed to create dye-labeled chitosan particulate systems.However, a greater part of approaches have been developed for the synthesis of dye-labeled chitosan molecular system using chemical reagents due to its low solubility.Numerous researches have addressed the utilization of chitosan as a fluorescence probe.These methods have a limited application in the medical and pharmaceutical fields, because most of them may be environmentally toxic or biologically hazardous.Herein, we focused on the environmentally friendly approach using a water-soluble chitosan derivative for bio-imaging.We report on the simple synthesis and optical properties for FITC-labeled chitosan oligomer in distilled water.
Authors: Hun Min Lee, Ja Young Cheon, Seoho Lee, Seung Hyun Lee, Su Young Kim, Dong Hoon Kang, Jeong Woo Heo, Won Ho Park
Institution: Chungnam National University
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W2472999992