Work

Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium

Year: 2016

Type: article

Abstract: We recently reported that therapeutic vaccination with live tumor antigen-producing Salmonella typhimurium rescues dysfunctional endogenous T cell responses and eradicates long-established tumors refractory to αCTLA-4 and αPD-L1 checkpoint inhibitor blockade. Here, we show that live intravenously injected or heat-killed (HK) intratumorally injected Salmonella typhimurium, even when not producing tumor antigen, synergize with adoptive T cell therapy to eradicate tumors. These data demonstrate that the combination of adoptive T cell transfer with the injection of live or dead Salmonella typhimurium is a promising approach for cancer treatment.

Source: OncoImmunology

DOI: 10.1080/2162402x.2015.1130207

Authors: David C. Binder, Ainhoa Arina, Frank Wen, Tony Tu, Ming Zhao, Robert M. Hoffman, Derek A. Wainwright, Hans Schreiber

Institutions: University of Chicago, AntiCancer (United States), University of California San Diego, Northwestern University

Language: English

Topic: Bacterial Cancer Therapy

Subfield: Biotechnology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913

Funders: National Institutes of Health, National Cancer Institute, National Institute of Neurological Disorders and Stroke

Awards: The interaction of IDO and Tregs Leads to Immunosuppression in Glioma, The interaction of IDO and Tregs Leads to Immunosuppression in Glioma, G3165211085, Methods of multi-omics with applications, Manipulation of Tumor Specific Immunity, The role of IDO and Th17 in an experimental mouse model of glioma, CD8+ T cells and Immunological Tumor Regression, G9000331551, The Robert H. Lurie Comprehensive Cancer Center

OpenAlex ID: W2473530948

FWCI: 1.772

Cites: 32

Cited by: 16

Related to: 10