Year: 2016
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Plasma branched-chain amino acids (BCAAs, including leucine, isoleucine and valine) were recently related to risk of type 2 diabetes (T2D). Dietary intake is the only source of BCAAs; however, little is known about whether habitual dietary intake of BCAAs affects risk of T2D. METHODS: We assessed associations between cumulative consumption of BCAAs and risk of T2D among participants from three prospective cohorts: the Nurses' Health Study (NHS; followed from 1980 to 2012); NHS II (followed from 1991 to 2011); and the Health Professionals Follow-up Study (HPFS; followed from 1986 to 2010). RESULTS: We documented 16 097 incident T2D events during up to 32 years of follow-up. After adjustment for demographics and traditional risk factors, higher total BCAA intake was associated with an increased risk of T2D in men and women. In the meta-analysis of all cohorts, comparing participants in the highest quintile with those in the lowest quintile of intake, hazard ratios (95%confidence intervals) were for leucine 1.13 (1.07-1.19), for isoleucine 1.13 (1.07-1.19) and for valine 1.11 (1.05-1.17) (all P for trend < 0.001). In a healthy subsample, higher dietary BCAAs were significantly associated with higher plasma levels of these amino acids (P for trend = 0.01). CONCLUSIONS: Our data suggest that high consumption of BCAAs is associated with an increased risk of T2D.
DOI: 10.1093/ije/dyw143
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Dietary Patterns and Risk of Cardiovascular Disease, G2111759553, G2214254730, Biochemical Markers in the nurses' Health Study Cohort, Biochemical and Genetic Markers of Type 2 Diabetes Risk, G3047652723, G3069166277, G34112852, Boston Nutrition Obesity Research Center, Dietary and Hormonal Determinants of Cancer in Women, G4482219006, G459566519, Genome-wide interactions with diet patterns on long-term weight change, Cancer Epidemiology Cohort in Male Health Professionals, G9000003116, G9000017222, G9000019617, G9000029955, G9000043482, G9000058679, G9000077354, G9000099730, G9000122174, G9000157792, G9000158339, G9000190097, RISK FACTORS FOR CVD IN WOMEN
OpenAlex ID: W2473554758