LncRNA MALAT1 exerts oncogenic functions in lung adenocarcinoma by targeting miR-204.
Year: 2016
Type: article
Abstract: Accumulating evidence indicates that the lncRNAs play a critical role in cancer progression and metastasis. In this study, we found that MALAT1 upregulation was associated with larger tumor size and lymph-node metastasis, and also correlated with shorter overall survival of lung adenocarcinoma patients. Furthermore, MALAT1 promotes EMT and metastasis of lung adenocarcinoma cells in vitro and in vivo. In particular, MALAT1 upregulated the expression of miR-204 target gene SLUG through competitively 'spongeing' miR-204. In summary we unveil a branch of the MALAT1/miR-204/SLUG pathway that regulates the progression of lung adenocarcinoma.
Source: PubMed Central
Authors: Jipeng Li, Jianhua Wang, Yin Chen, Shanfeng Li, Mingwei Jin, Huaying Wang, Zhe Chen, Wanjun Yu
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2473555904