Work

The life and works of S100P - from conception to cancer.

Year: 2016

Type: review

Abstract: Since its discovery in 1992, the small, 10.4 kDa calcium-binding protein S100P has gained the attention of researchers from different scientific fields due to its potential roles in both healthy and neoplastic tissues. Although not ubiquitously expressed, in tissues where it is present, S100P is associated with distinct changes in cellular behaviour. In this review we have summarized the evolutionary history of S100P, its expression and involvement in implantation and human embryonic development, as well as important functions in normal tissue and cancer. Finally, we have demonstrated its pivotal role as a potential diagnostic and therapeutic target, which opens promising avenues for further fruitful research on S100P.

Source: PubMed

Authors: Filip Prica, Tomasz Radon, Yuzhu Cheng, Tatjana Crnogorac-Jurcevic

Institutions: Queen Mary University of London, Barts Cancer Institute, Newcastle University

Language: English

Topic: S100 Proteins and Annexins

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2473709326

FWCI: 0.433

Cites: 140

Cited by: 57

Related to: 10