Work

Structure and Function of HLA-G

Year: 2015

Type: article

Abstract: HLA-G is a nonclassical HLA class Ib, which is located on chromosome 6 (6p.21.3). In contrast to HLA class I molecules, HLA-G has restricted polymorphism. Expression of this molecule in the physiological conditions limits to certain tissues such as thymus, cornea, nail matrix, trophoblast and pancreas. Up to now, 50 alleles of HLA-G molecules have been discovered with 16 distinct functional proteins. Alternative splicing of RNA primary transcript results in seven isoforms including four membrane bound (G1-G4) and three soluble (G5-G7) isoforms. Today, many roles have been described for HLA-G molecule in various physiological and pathological conditions such as pregnancy, transplantation, autoimmune and infectious diseases. Induction of HLA-G expression is one of the immune system evasion mechanisms in some infectious and tumoral conditions. The importance of HLA- G expression during pregnancy and establishment of fetal-maternal tolerance has been proved. In this review paper we discussed the genetics, biology and the role of HLA-G molecule in some physiological and pathological conditions.

Source: Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Māzandarān/Journal of Mazandaran University of Medical Sciences

Authors: Saeideh Sadat Shobeiri, Versa Omrani‐Nava, Saeid Abediankenari

Institution: Mazandaran University of Medical Sciences

Language: English

Topic: Reproductive System and Pregnancy

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2474509252

FWCI:

Cites: 82

Cited by:

Related to: 10