Work

Allergic contact dermatitis to topical prodrugs used in photodynamic therapy

Year: 2016

Type: article

Abstract: Topical photodynamic therapy (PDT) is a well-established treatment for actinic keratosis, Bowen's disease and superficial basal cell carcinoma and its use has also been explored for a variety of other indications.(1,2,3) Treatment involves application of a pro-drug (either 5-aminolaevulinic acid (ALA) or its methlyester, methylaminolevulinate (MAL)) which is preferentially taken up by dysplastic or neoplastic cells and converted into the active photosensitiser protoporphyrin IX (PPIX). Subsequent activation of PPIX by red light results in the production of cytotoxic oxygen species, inflammation and relatively selective diseased tissue destruction. This article is protected by copyright. All rights reserved.

Source: Photodermatology Photoimmunology & Photomedicine

DOI: 10.1111/phpp.12252

Authors: Helen Cordey, Sally Ibbotson

Institutions: University of Dundee, Ninewells Hospital

Language: English

Topic: Contact Dermatitis and Allergies

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2475196167

FWCI: 1.452

Cites: 6

Cited by: 7

Related to: 10