Phage‐Enabled Nanomedicine: From Probes to Therapeutics in Precision Medicine
Year: 2016
Type: review
Abstract: Both lytic and temperate bacteriophages (phages) can be applied in nanomedicine, in particular, as nanoprobes for precise disease diagnosis and nanotherapeutics for targeted disease treatment. Since phages are bacteria-specific viruses, they do not naturally infect eukaryotic cells and are not toxic to them. They can be genetically engineered to target nanoparticles, cells, tissues, and organs, and can also be modified with functional abiotic nanomaterials for disease diagnosis and treatment. This Review will summarize the current use of phage structures in many aspects of precision nanomedicine, including ultrasensitive biomarker detection, enhanced bioimaging for disease diagnosis, targeted drug and gene delivery, directed stem cell differentiation, accelerated tissue formation, effective vaccination, and nanotherapeutics for targeted disease treatment. We will also propose future directions in the area of phage-based nanomedicines, and discuss the state of phage-based clinical trials.
Institutions: University of Oklahoma, Zhejiang University
Language: English
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: Collaborative Research: Chemical and Biological Quantum Nanosensors Based on Nanoparticle Molecules, UNS: Translation of nano-biorecognition into macroscopic counting for attomolar detection of biomolecules, Virus-based nanoparticles for detecting breast cancer biomarkers, Hiring Non-toxic Virus Nanoparticles to Count Cancer Biomarker Molecules, Selective tumor inhibition by tumor-homing angiogenesis-suppressing nanofibers
OpenAlex ID: W2476758090