Work

Full-Genome Sequence of a Neuroinvasive West Nile Virus Lineage 2 Strain from a Fatal Horse Infection in South Africa

Year: 2016

Type: article

Abstract: We report here the complete genome sequence of a lineage 2 West Nile virus (WNV) strain that resulted in fatal neurological disease in a horse in South Africa. Several recent reports exist of neurological disease associated with lineage 2 WNV in humans and horses in South Africa and Europe; however, there are a lack of sequencing data from recent fatal cases in Southern Africa, where these strains likely originate. A better understanding of the genetic composition of highly neuroinvasive lineage 2 strains may facilitate the identification of putative genetic factors associated with increased virulence.

Source: Genome Announcements

DOI: 10.1128/genomea.00740-16

Authors: Juliet L. D. Mentoor, Alison B. Lubisi, Truuska Gerdes, Stacey Human, June H. Williams, Marietjie Venter

Institutions: University of Pretoria, Onderstepoort Veterinary Institute, Centers for Disease Control and Prevention, Centers for Disease Control and Prevention

Language: English

Topic: Mosquito-borne diseases and control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Research Foundation, National Health Laboratory Service