Year: 2010
Type: other
Abstract: Trends and conclusionThe successful sequencing of whole genomes has offered tremendous opportunities to understand various life processes/biological phenomena.Modern day research offers a remarkable set of challenges, such as computationally predicting the development of a single cell into an adult, synchronized functioning of the cells as a complete organism, reconstruction of an organism and many more.The answer to all these may not lie within the genome sequence itself but in the network of molecular interactions, thus emphasizing the importance of maintaining the database, not only of the building blocks but also their interactions for methodical functional analysis as demonstrated in the book.Also there is a great potential for designing the drugs efficiently and cost effectively based on the knowledge of the target.Current bioinformatics has an essential role to play in interpreting genomic, transcriptomic, and proteomic data generated by high-throughput experimental technologies, as well as interpreting information gathered from research in the field of traditional biology and medicine.Sequence-based methods of analyzing individual genes or proteins, and annotation of the whole genome or transcriptome, may now lead towards personalized medicine.This book discussed various aspects of knowledge-driven and data-analysis approaches for acquisition, maintenance, integration, and interpretation of biomedical data in Section 1 and 2. Section 3 covered various methods for exploring genomes of a wide variety of species.Section 4 illustrated biomolecular relationships and networks, their analysis and applications.The focus of this book has been on the integration and application of various methods for analysis and interpretation of the biomedical data, which can lead to break-through discovery for understanding systemic functional behavior of the cell and the organism.To achieve a high level of coordination and management of data, participation of researchers working with molecular data and scientific literature is vital.This is apparent from the backgrounds of the contributing authors of each chapter in the book.To help in correspondence, email is included for each chapter.
Authors: Gil Alterovitz, Marco Ramoni
Institutions: Harvard University, Massachusetts Institute of Technology
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W2477351232