Rapidly disintegrating fast release tablets of diazepam using solid dispersion: development and evaluation
Year: 2008
Type: article
Abstract: This study presents development of diazepam tablets, which could provide rapid disintegration and immediate release of drug in oral cavity. Tablets were prepared by conventional wet granulation and direct compression methods. Diazepam was formulated with polyethylene glycoi (PEG-6000) as a solid dispersion to increase aqueous solubility and dissolution of drug. Croscarmellose sodium and Aerolac R were used in tablet formulation to achieve rapid disintegration of tablets prepared respectively by wet granulation and direct compression methods. Tablets developed in this study disintegrated in 37 seconds (wet granulation) and 31 seconds (direct compression) and released 85% in about 21-22 min, whereas marketed tablet disintegrates in 116 seconds and release same amount of drug in 130 min. This study indicates that rapidly disintegrating fast release tablets can be prepared by the conventional methods utilizing the existing infrastructure of tablet manufacturing.
Authors: Tapan Kumar Giri, Parimai Jana, Biswanath Sa
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2480248251