Work

Importance of Receptor-targeted Systems in the Battle Against Atherosclerosis

Year: 2013

Type: article

Abstract: Atherosclerosis is the leading cause of death in the Western World and has been for decades a field of intense research. Yet, while there is a rich and diverse literature describing in detail the players and mechanisms involved in this complex disease in cell and animal models, we remain today with virtually no reliable markers for early diagnosis and targeted treatments options. This review is centered upon the latter. We summarize the latest studies focused on detecting endothelial dysfunction during the early stages of atherosclerosis, when the disease is asymptomatic and describe strategies recently proposed to image and target advanced plaque.

Source: Current Pharmaceutical Design

DOI: 10.2174/1381612811319330010

Authors: Elisabet Rosas, Igor Sobenin, Alexander Orekhov, Elazer Edelman, Mercedes Balcells

Institutions: Institut Químic de Sarrià, Universitat Ramon Llull, Massachusetts Institute of Technology, Institute for Atherosclerosis Research, Brigham and Women's Hospital

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences