Emerging non-traditional biomarkers for assessing long term risk in renal transplant recipients
Year: 2016
Type: dissertation
Abstract: Background: Inflammatory markers show significant associations with cardiovascular events and all-cause mortality after kidney transplantation. Neopterin, reflecting interferon-c-release, may better reflect the proinflammatory state of recipients than less specific markers. Methods: Kidney transplant recipients in the Assessment of LEscol in Renal Transplant (ALERT) trial were examined and investigated for an association between serum neopterin and subsequent clinical events: graft loss, major cardiovascular events (MACE) and all-cause mortality. Results: After adjustment for established and emerging risk factors neopterin expressed as neopterin-to-creatinine ratio was significantly associated with MACE (p = 0.009) and all-cause mortality (p = 0.002). Endpoints were more frequent with increasing quartiles of neopterin-to- creatinine ratio. The incidence rates of MACE and all-cause mortality were significantly increased in the upper quartiles compared with the first. Conclusions: This long-term prospective analysis in stable kidney allograft recipients suggests that neopterin is associated with long-term risk of cardiovascular events and all-cause mortality, but not renal outcomes. Hege Pihlstrom, Geir Mjoen, Winfried M€ arz, Dag Olav Dahle, Sadollah Abedini, Ingar Holme, Bengt Fellstr€ om, Alan Jardine, Stefan Pilz and Hallvard Holdaas Department of Organ Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway, Division of Nephrology, Department of Medicine, Oslo University Hospital Ulleval, Oslo, Norway, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria, Synlab Center of Laboratory Diagnostics, Heidelberg, Germany, Medical Faculty Mannheim, Mannheim Institute of Public Health, Social and Preventive Medicine, University of Heidelberg, Mannheim, Germany, Division of Nephrology, Department of Medicine, Sykehuset i Vestfold, Tonsberg, Norway, Department of Research and Development, Oslo University Hospital Ulleval, Oslo, Norway, Division of Nephrology, Department of Internal Medicine, Uppsala University Hospital, Uppsala, Sweden, British Heart Foundation, Glasgow Cardiovascular Researh Centre, Glasgow, UK, Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria and Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Centre, Amsterdam, the Netherlands
Author: Hege Pihlstrøm
Language: English
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2482629020