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Blockade of interleukin-27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing Foxp3 expression

Year: 2016
Type: article
Abstract: Tregs, indicating that IL-27 inhibition had differential effects on IL-10 production and preserved a mechanistic pathway by which Tregs are known to suppress GVHD. Targeting of IL-27 therefore represents a novel strategy for the in vivo expansion of Tregs and subsequent prevention of GVHD without the requirement for ex vivo cellular manipulation, and provides additional support for the critical proinflammatory role that members of the IL-6 and IL-12 cytokine families play in GVHD biology.
Source: Blood
DOI: 10.1182/blood-2016-02-698241
Authors: Ludovic Belle, Kimberle Agle, Vivian Zhou, Cheng Yin-Yuan, Richard Komorowski, Daniel Eastwood, Brent Logan, Jie Sun, Nico Ghilardi, Daniel Cua, Calvin B. Williams, Melanie Gaignage, Reece Marillier, Jacques van Snick, William R. Drobyski
Institutions: Medical College of Wisconsin, Indiana University Indianapolis, Indiana University School of Medicine, Genentech, Merck & Co., Inc., Rahway, NJ, USA (United States), de Duve Institute, UCLouvain, Ludwig Cancer Research
Language: English
Subfield: Immunology
Open Access status: bronze
Funders: Midwest Athletes Against Childhood Cancer, Wallonie-Bruxelles International, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases
Awards: Regulatory T Cell Populations in Graft versus Host Disease, Regulation of pulmonary anti-viral immunity in normal and obese hosts, G435608594, Molecular regulation of protective CD8 immunity against influenza infection, Simultaneously boosting both humoral and cellular immunity following vaccination, Inflammatory Cytokine Networks in Gastrointestinal Tract Graft Versus Host Disease
OpenAlex ID: W2483959132
FWCI: 2.83
Cites: 52
Cited by: 41
Related to: 10