AGEs and Bone Fracture
Year: 2016
Type: article
Abstract: Cancellous bone cores were obtained from tibial plateaus of human donors (age: 39-87). Each score was scanned (Scanco Medical AG) to obtain bone mineral density (BMD) and assigned into two groups [(Group 1: Mean age = 57 ±17; N=5); (Group 2: Mean age = 66±20; N=5)] such that their BMD was not different (p=0.92). Cores were tested via unconfined compression tests [1] to determine several mechanical variables including toughness (defined as area under the stress-strain curve). A bone slice was cut for the determination of advanced glycation end-products (AGEs, measured as ng fluorescence/mg of collagen) using protocols well established in our lab [1]. Consistent with clinical studies [2], the results showed that, in contrast to BMD, the toughness values of the two groups were significantly different (p=0.01). More importantly, total AGEs were significantly higher in low-toughness than in the high-toughness group. Higher AGEs have been shown to cause increased bone fragility [3]. Consistent with these results, our study on a larger cohort shows that AGEs predict post-yield fracture properties of tibial cancellous bone independently of BMD [4].
Authors: Vashishth, Deepak, Karim, Lamya
Institution: Rensselaer Polytechnic Institute
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2484326304