Regulatory Roles of Fluctuation-Driven Mechanotransduction in Cell Function
Year: 2016
Type: review
Abstract: Cells in the body are exposed to irregular mechanical stimuli. Here, we review the so-called fluctuation-driven mechanotransduction in which stresses stretching cells vary on a cycle-by-cycle basis. We argue that such mechanotransduction is an emergent network phenomenon and offer several potential mechanisms of how it regulates cell function. Several examples from the vasculature, the lung, and tissue engineering are discussed. We conclude with a list of important open questions.
Source: Physiology
Institution: Boston University
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
Awards: Endogenous surfactant therapy for the developing lung, G2154803354, Advanced Image-Based Approach to Assess How Fibrillar Collagen Modulates Airway Reactivity, G2957381208, G3763101721, Regulatory roles of variable mechanical stimuli in cell function, Extracellular determinants of airway smooth muscle force: A new paradigm for sust, G6568421330, Extracellular determinants of airway smooth muscle force: A new paradigm for sust
OpenAlex ID: W2484494929