Work

Genomic correction of familial cardiomyopathy in human engineered cardiac tissues

Year: 2016

Type: article

Abstract: In this study, we used three-dimensional human engineered cardiac tissue technology to directly show that phospholamban (PLN) R14del mutation impairs cardiac contractility and to demonstrate restoration of contractile properties with targeted genetic correction of this inheritable form of dilated cardiomyopathy.

Source: European Heart Journal

DOI: 10.1093/eurheartj/ehw307

Authors: Francesca Stillitano, Irene C. Turnbull, Ioannis Karakikes, Mathieu Nonnenmacher, Peter Backeris, Jean-Sébastien Hulot, Evangelia G. Kranias, Roger J. Hajjar, Kevin D. Costa

Institutions: Icahn School of Medicine at Mount Sinai, Stanford Cardiovascular Institute, Assistance Publique – Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Fondation pour l’innovation en Cadiométabolisme et Nutrition, Université Pierre-et-Marie-Curie, University of Cincinnati

Language: English

Topic: Cardiomyopathy and Myosin Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute

Awards: Calcium Handling in Cardiac Pathophysiology, Cardiac Sarcoplasmic Reticulum Calcium Cycling Proteins

OpenAlex ID: W2484920250

FWCI: 8.229

Cites: 7

Cited by: 77

Related to: 10