Work

Irritable bowel syndrome, the microbiota and the gut-brain axis

Year: 2016

Type: review

Abstract: Irritable bowel syndrome is a common functional gastrointestinal disorder and it is now evident that irritable bowel syndrome is a multi-factorial complex of changes in microbiota and immunology. The bidirectional neurohumoral integrated communication between the microbiota and the autonomous nervous system is called the gut-brain-axis, which integrates brain and GI functions, such as gut motility, appetite and weight. The gut-brain-axis has a central function in the perpetuation of irritable bowel syndrome and the microbiota plays a critical role. The purpose of this article is to review recent research concerning the epidemiology of irritable bowel syndrome, influence of microbiota, probiota, gut-brain-axis, and possible treatment modalities on irritable bowel syndrome.

Source: Gut Microbes

DOI: 10.1080/19490976.2016.1218585

Authors: Hans Raskov, Jakob Burcharth, Hans-Christian Pommergaard, Jacob Rosenberg

Institutions: University of Copenhagen, Herlev Hospital, Zealand University Hospital, Hvidovre Hospital

Language: English

Topic: Gastrointestinal motility and disorders

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,060