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A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation

Year: 2016

Type: article

Abstract: UNLABELLED: Sulforaphane (SFN), a naturally occurring isothiocyanate found in cruciferous vegetables, is implicated as a possible therapy for airway inflammation via induction of the transcription factor NF-E2-related factor 2 (NRF2). In this proof-of-concept clinical study, we show that supplementation of SFN with broccoli sprout homogenate in healthy human subjects did not induce expression of antioxidant genes or protect against neutrophilic airway inflammation in an ozone-exposure model. Therefore, dietary sulforaphane supplementation is not a promising candidate for larger scale clinical trials targeting airway inflammation. TRIAL REGISTRATION: NCT01625130 . Registered 19 June, 2012.

Source: Respiratory Research

DOI: 10.1186/s12931-016-0406-8

Authors: Charity G. Duran, Allison J. Burbank, Katherine H. Mills, Heather R. Duckworth, Maria M. Aleman, Matthew J. Kesic, David B. Peden, Yinghao Pan, Haibo Zhou, Michelle L. Hernandez

Institutions: University of North Carolina at Chapel Hill, Methodist University, University of North Carolina Health Care

Language: English

Topic: Genomics, phytochemicals, and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,490

Funders: U.S. Environmental Protection Agency, Environmental Protection Agency, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Environmental Health Sciences

Awards: G1017297203, G189881835, G208256123, G2535096693, G2609572443, G3494341100, G4092615068, G6555922249, Down-regulation of oxidant-induced airway inflammation though modulation of NRF2, UNC Center for Environmental Health and Susceptibility, UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program, G901184120

OpenAlex ID: W2491926929

FWCI: 2.257

Cites: 13

Cited by: 55

Related to: 10