Work

The Benefits of Early Antiretroviral Therapy for HIV Infection: How Early is Early Enough?

Year: 2016

Type: article

Abstract: The case of the “Berlin Patient” is well-known. In 2007, an HIV-infected adult with leukemia underwent allogeneic hematopoietic stem cell transplant and was cured of his cancer (Hutter et al., 2009). As the donor was homozygous for the CCR5Δ32 deletion (which makes CD4+ T cells difficult to infect with HIV), the repopulated immune system lacked any detectable HIV and the patient has been apparently been cured. Two subsequent allogeneic transplants performed under potent ART (which protected the donor cells from de novo infection) resulted in a dramatic reduction in the frequency of cells harboring replication-competent HIV (generally referred to as the HIV “reservoir”) (Henrich et al., 2014).

Source: EBioMedicine

DOI: 10.1016/j.ebiom.2016.08.009

Authors: Sulggi A. Lee, Steven G. Deeks

Institution: University of California, San Francisco

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,780