Somatic KCNJ5 mutation occurring early in adrenal development may cause a novel form of juvenile primary aldosteronism
Year: 2016
Type: article
Study design: Case Report
Abstract: We report a case of non-familial juvenile primary aldosteronism (PA). Super-selective adrenal venous sampling identified less aldosterone production in the right inferior adrenal segment than others. Bilateral adrenalectomy sparing the segment normalized blood pressure and improved PA. Both adrenals had similar histologies, consisting of a normal adrenal cortex and aldosterone synthase-positive hyperplasia/adenoma. An aldosterone-driving KCNJ5 mutation was detected in the lesions, but not in the histologically normal cortex. After taking into account that the two adrenal glands displayed a similar histological profile, as well as the fact that hyperplastic lesions in both glands exhibited a common KCNJ5 mutation, we conclude that the specific mutation may have occurred at an adrenal precursor mesodermal cell, at an early stage of development; its daughter cells were mixed with non-mutant cells and dispersed into both adrenal glands, resulting into a form of the condition known as genetic mosaicism.
Authors: Ai Tamura, Koshiro Nishimoto, Tsugio Seki, Yoko Matsuzawa, Jun Saito, Masao Omura, Celso E. Gomez-Sanchez, Kohzoh Makita, Seishi Matsui, Nobukazu Moriya, Atsushi Inoue, Maki Nagata, Hironobu Sasano, Yasuhiro Nakamura, Yuto Yamazaki, Yasuaki Kabe, Kuniaki Mukai, Takeo Kosaka, Mototsugu Oya, Sachiko Suematsu, Tetsuo Nishikawa
Institutions: Yokohama Rosai Hospital, Keio University, Saitama International Medical Center, Saitama Medical University, California University of Science and Medicine, University of Mississippi Medical Center, G.V. (Sonny) Montgomery VA Medical Center, Nerima Hikarigaoka Hospital, Tohoku University, Keio University Hospital
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,510
Funders: Japan Agency for Medical Research and Development, Ministry of Health, Labour and Welfare, Yamaguchi Endocrine Research Foundation, National Institutes of Health, Japan Society for the Promotion of Science, National Heart, Lung, and Blood Institute, Core Research for Evolutional Science and Technology
Awards: G1099776516, G1356194580, Role of Mineralocorticoids in Hypertension, Analysis of functional regulation of PGMRC1, Ealucidation of progression from aldosterone-producing cell cluster leading to aldosterone-producing adenoma, Adrenocortical remodeling develops autonomous production of aldosterone
OpenAlex ID: W2493807669