Work

Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition

Year: 2016

Type: article

Source: Bioorganic & Medicinal Chemistry Letters

DOI: 10.1016/j.bmcl.2016.07.042

Authors: Michael R. Wood, Meredith J. Noetzel, James C. Tarr, Alice L. Rodriguez, Atin Lamsal, Sichen Chang, Jarrett J. Foster, Emery Smith, Peter Chase, Peter S. Hodder, Darren W. Engers, Colleen M. Niswender, Nicholas J. Brandon, Michael W. Wood, Mark E. Duggan, P. Jeffrey Conn, Thomas M. Bridges, Craig W. Lindsley

Institutions: Vanderbilt University, Vanderbilt University Medical Center, Scripps Research Institute, Amgen (United States)

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: William K. Warren Foundation, National Institutes of Health, National Institute of Mental Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: The Comprehensive Center for Chemical Probe Discovery and Optimization at Scripps, The Vanderbilt Specialized Chemistry Center for Accelerated Probe Development, G3630766387, Muscarinic Receptor Activators as Antipsychotic Agents, Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt University, G8598239384

OpenAlex ID: W2494601158

FWCI: 2.08

Cites: 25

Cited by: 12

Related to: 10