Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase
Year: 2016
Type: article
Abstract: A recently discovered class of endogenous mammalian lipids, branched fatty acid esters of hydroxy fatty acids (FAHFAs), possesses anti-diabetic and anti-inflammatory activities. Here, we identified and validated carboxyl ester lipase (CEL), a pancreatic enzyme hydrolyzing cholesteryl esters and other dietary lipids, as a FAHFA hydrolase. Variants of CEL have been linked to maturity-onset diabetes of the young, type 8 (MODY8), and to chronic pancreatitis. We tested the FAHFA hydrolysis activity of the CEL MODY8 variant and found a modest increase in activity as compared with that of the normal enzyme. Together, the data suggest that CEL might break down dietary FAHFAs.
Source: Biochemistry
Authors: Matthew J. Kolar, Siddhesh S. Kamat, William H. Parsons, Edwin A. Homan, Tim Maher, Odile D. Peroni, Ismail Syed, Karianne Fjeld, Anders Molven, Barbara B. Kahn, Benjamin F. Cravatt, Alan Saghatelian
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: green
Awards: G214752006, G3593534703, G3680258357, Metabolic effects of adipose lipogenesis, G4128202873, Identification and Therapeutic Valiation of Adipocyte Serine Hydrolases of Metab, G6512685291, G680976502, G713717172, Glucose Transporter Regulation in Obesity and Diabetes, Medical Scientist Training Program, G9000272408, Cancer Center Support Grant (CCSG)
OpenAlex ID: W2495528719