Year: 2016
Type: article
Abstract: Aberrant activation of the PI3K and NF-κB pathways occurs frequently in human B-cell lymphomas. 1 , 2 Recent studies suggested reciprocal molecular interactions between these two pathways in lymphomagenesis. For example, PI3K inhibition suppresses NF-κB activity in human Burkitt’s lymphoma and diffuse large B-cell lymphoma, 3 , 4 while blockade of NF-κB causes suppression of PI3K activity in primary effusion lymphoma cell lines. 5 Despite frequent alterations and molecular interactions of these two pathways in human lymphomas, genetic activation of anyone of these two pathways was not sufficient to initiate lymphoma development in mice. 6 , 7 , 8
Source: Leukemia
DOI: 10.1038/leu.2016.204
Authors: H Y Jin, M Lai, J Shephard, C Xiao
Institution: Scripps Research Institute
Language: English
Topic: NF-κB Signaling Pathways
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,190
Awards: Regulation of T Follicular Helper Cell Differentiation by MicroRNAs, Deep Sequencing of Small Regulatory RNAs in Diffuse Large B cell Lymphoma, The Role of miR-17~92 in Autoimmune Diseases, Regulation of T Follicular Helper Cell Differentiation by MicroRNAs, Regulation of T Follicular Helper Cell Differentiation by MicroRNAs, Functional Analysis of MicroRNAs in Lymphocyte Development and Immune Tolerance
OpenAlex ID: W2497761391