Work

Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era

Year: 2016

Type: article

Abstract: Stereotactic body radiation therapy (SBRT) utilizing a small number of high-dose radiation therapy fractions continues to expand in clinical application. Although many approaches have been proposed to radiosensitize tumors with conventional fractionation, how these radiosensitizers will translate to SBRT remains largely unknown. Here, we review our current understanding of how SBRT eradicates tumors, including the potential contributions of endothelial cell death and immune system activation. In addition, we identify several new opportunities for radiosensitization generated by the move toward high dose per fraction radiation therapy.

Source: The Cancer Journal

DOI: 10.1097/ppo.0000000000000203

Authors: Everett J. Moding, Yvonne M. Mowery, David G. Kirsch

Institutions: Moses H Cone Memorial Hospital, Duke University, Duke Medical Center

Language: English

Topic: Advanced Radiotherapy Techniques

Subfield: Radiation

Field: Physics and Astronomy

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: GlaxoSmithKline, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Duke Cancer Institute