Work

Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies

Year: 2016

Type: article

Study design: Observational Study

Abstract: cells, and a higher T regulatory cell level of programmed cell death-1 expression compared with HIV-1-infected individuals without bnAbs. Thus, induction of HIV-1 bnAbs may require vaccination regimens that transiently mimic immunologic perturbations in HIV-1-infected individuals.

Source: Science Immunology

DOI: 10.1126/sciimmunol.aag0851

Authors: M. Anthony Moody, Isabela Pedroza-Pacheco, Nathan A. Vandergrift, Cecilia Chui, Krissey E. Lloyd, Robert Parks, Kelly A. Soderberg, Ane T. Ogbe, Myron S. Cohen, Hua-Xin Liao, Feng Gao, Andrew J. McMichael, David C. Montefiori, Laurent Verkoczy, Garnett Kelsoe, Jinghe Huang, Patrick R. Shea, Mark Connors, Persephone Borrow, Barton F. Haynes

Institutions: Duke University, Duke Medical Center, University of Oxford, University of North Carolina at Chapel Hill, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Columbia University

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, Medical Research Council, National Institute of Allergy and Infectious Diseases

Awards: (CHAVI) Center for HIV/AIDS Vaccine Immunology, G185716262, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, Single molecule imaging of HIV Env, G8320254048, G926065654

OpenAlex ID: W2500524648

FWCI: 12.41

Cites: 114

Cited by: 128

Related to: 10