Year: 2016
Type: article
Abstract: OBJECTIVE: To investigate the psychometric properties of the Clinical Dementia Scale-frontotemporal lobar degeneration (CDR-FTLD) psychometric properties using Rasch analysis and its sensitivity distinguishing disease progression between FTLD and Alzheimer's disease (AD). METHODS: Of 603 consecutive patients from the National Alzheimer Coordinating Center dataset (FTLD = 350; AD = 253), 120 FTLDs were included in a Rasch analysis to verify CDR-FTLD psychometric properties; 483 (FTLD = 230; AD = 253) were included to analyse disease progression, with 195 (FTLD = 82; AD = 113) followed-up (24 months). RESULTS: The CDR-FTLD demonstrated good consistency, construct and concurrent validity and correlated well with mini-mental state examination (MMSE) and disease duration (ps < 0.05). At baseline, FTLD showed greater dementia severity than AD after matched for MMSE and disease duration (p < 0.001). Independent Rasch analyses demonstrated different patterns of progression for FTLD and AD in terms of the domains initially and then subsequently affected with disease progression. At follow-up, although MMSE showed significant changes (p < 0.05), these were greater on the CDR-FTLD (p < 0.001). CONCLUSION: The CDR-FTLD satisfactorily measures dementia severity and change in FTLD, distinguishing disease progression between FTLD and AD, with clear implications for care, prognosis and future clinical trials. © 2016 The Authors. International Journal of Geriatric Psychiatry published by John Wiley & Sons, Ltd.
DOI: 10.1002/gps.4556
Authors: Eneida Mioshi, Emma Flanagan, David Knopman
Institutions: University of East Anglia, University of Cambridge, Mayo Clinic
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,600
Awards: UC Davis Alzheimer's Disease Core Center, Indiana Alzheimer Disease Center, University of Kentucky Alzheimer's Disease Core Center, Neurobiology of Alzheimer's Disease and Aging, Alzheimer's Disease Research Center, National Alzheimer's Coordinating Center, UCSD Alzheimer's Disease Research Center P50, Alzheimer's Disease Research Center, UCLA Alzheimer's Disease Research Center, Alzheimer's Disease Core Center, The Alzheimer's Disease Research Center at the University of California, Irvine, Oregon Alzheimer's Disease Center, Rush Alzheimer's Disease Core Center, Enhancing activity participation in Frontotemporal dementia, G540133491, Alzheimer's Disease Core Center, Alzheimer's Disease Research Center - Overall, Wisconsin Alzheimer's Disease Research Center, University of Kansas Alzheimer's Disease Core Centers, Alzheimer's Disease Research Center, Alzheimer Disease Research Center, Arizona Alzheimer's Disease Core Center, Johns Hopkins Alzheimer's Disease Research Center, Boston University Alzheimer's Disease Center, Alzheimer's Disease Research Center, Massachusetts Alzheimer's Disease Research Center, Alzheimer's Disease Core Center, Emory Alzheimer's Disease Center, New Approaches to Dementia Heterogeneity, Mayo Alzheimer's Disease Research Center
OpenAlex ID: W2501092250