Work

Is the Mouse a Good Model of Human PPARγ-Related Metabolic Diseases?

Year: 2016

Type: article

Abstract: With the increasing number of patients affected with metabolic diseases such as type 2 diabetes, obesity, atherosclerosis and insulin resistance, academic researchers and pharmaceutical companies are eager to better understand metabolic syndrome and develop new drugs for its treatment. Many studies have focused on the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ), which plays a crucial role in adipogenesis and lipid metabolism. These studies have been able to connect this transcription factor to several human metabolic diseases. Due to obvious limitations concerning experimentation in humans, animal models-mainly mouse models-have been generated to investigate the role of PPARγ in different tissues. This review focuses on the metabolic features of human and mouse PPARγ-related diseases and the utility of the mouse as a model.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms17081236

Authors: Attila Pap, Ixchelt Cuaranta-Monroy, Matthew Peloquin, Laszlo Nagy

Institutions: University of Debrecen, Sanford Burnham Prebys Medical Discovery Institute

Language: English

Topic: Peroxisome Proliferator-Activated Receptors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499