Work

Generalised Glucocorticoid Resistance

Year: 2008

Type: article

Abstract: The gene encoding hGRα(hGR gene) is one locus on the long arm of chromosome 5 (q31.3), and consists of nine exons spanning over 150kb. Expressed hGRαis a panel of eight amino terminal translational isoforms of varying lengths, each of which consists of three subdomains: the N-terminal (NTD), the DNA-binding (DBD) and the ligand-binding (LBD) domains. In our expression and functional studies referred to here we have employed as representative the longest GRαisoform, comprising 777 amino acids.

Source: US Endocrinology

DOI: 10.17925/use.2008.04.2.100

Authors: George P Chrousos, Tomoshige Kino, Evangelia Charmandari

Institutions: Biomedical Research Foundation of the Academy of Athens, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Language: English

Topic: Adrenal Hormones and Disorders

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development

OpenAlex ID: W2505079485