Work

Regulation of Gastrointestinal Smooth Muscle Function by Interstitial Cells

Year: 2016

Type: article

Abstract: Interstitial cells of mesenchymal origin form gap junctions with smooth muscle cells in visceral smooth muscles and provide important regulatory functions. In gastrointestinal (GI) muscles, there are two distinct classes of interstitial cells, c-Kit(+) interstitial cells of Cajal and PDGFRα(+) cells, that regulate motility patterns. Loss of these cells may contribute to symptoms in GI motility disorders.

Source: Physiology

DOI: 10.1152/physiol.00006.2016

Authors: Kenton M. Sanders, Yoshihiko Kito, Sung Jin Hwang, Sean M. Ward

Institutions: University of Nevada, Reno, Saga University

Language: English

Topic: Gastrointestinal motility and disorders

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases