Work

On the Question of the Pathogenesis of Hiv-infection: the Role of Immune Activation in Progression of Disease

Year: 2012

Type: article

Abstract: Hyperactivaion of immme system is considered by most investigators as importantfactor, contributing to progression of HIV-infection and development ofAIDS. In the review modern knowledge about mechanisms and results of activation of immune system during HIV-infection are presented. HIV itself, opportunistic pathogens and components of gut microbiota, first of all, endotoxins ofgram-negative bacteria are considered as probable "activators" of immune system. High levels of endotoxin and markers of immune activation are associated with an even greater rate of progression of HIV-infection.

Source: Epidemiology and Infectious Diseases

DOI: 10.17816/eid40663

Authors: G. R. Khasanova, I. G. Mustafin, V. A. Anokhin

Institutions: Kazan State Medical University, Government of the Republic of Tatarstan

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W3150178369

FWCI:

Cites: 59

Cited by: 1

Related to: 10