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Imprinting and recalling cortical ensembles

Year: 2016
Type: article
Abstract: Neuronal ensembles are coactive groups of neurons that may represent building blocks of cortical circuits. These ensembles could be formed by Hebbian plasticity, whereby synapses between coactive neurons are strengthened. Here we report that repetitive activation with two-photon optogenetics of neuronal populations from ensembles in the visual cortex of awake mice builds neuronal ensembles that recur spontaneously after being imprinted and do not disrupt preexisting ones. Moreover, imprinted ensembles can be recalled by single- cell stimulation and remain coactive on consecutive days. Our results demonstrate the persistent reconfiguration of cortical circuits by two-photon optogenetics into neuronal ensembles that can perform pattern completion.
Source: Science
DOI: 10.1126/science.aaf7560
Institution: Columbia University
Language: English
Open Access status: green
Funders: Burroughs Wellcome Fund, Uehara Memorial Foundation, Defense Advanced Research Projects Agency, National Institute of Mental Health, National Eye Institute, National Center for Chronic Disease Prevention and Health Promotion, Army Research Office, Army Research Laboratory
Awards: G1510335116, G4012432327, A Holographic Module for Multiphoton Microscopes in Neuroscience, Functional consequences of GABAergic inhibition of dendritic spines at puberty, G6431169643, Imaging Functional Connectivity in Visual Cortex, Functional connectomics of the neocortical microcircuit, A novel 3D microscope for imaging and photostimulation, Two-photon optical control of astrocytic function
OpenAlex ID: W2508029759
FWCI: 16.42
Cites: 40
Cited by: 278
Related to: 10