Work

CD3/CD19 Depletion with Targeted T Cell Add-Back Results in Stable Engraftment and Minimal GVHD in Pediatric Patients with Bone Marrow Failure Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplantation

Year: 2016

Type: article

Abstract: For patients with bone marrow failure (BMF) lacking an HLA matched related donor (MRD), traditional approaches for unrelated donor stem cell transplantation have utilized bone marrow as a stem source due to high rates of GvHD and poorer survival with T cell replete peripheral blood stem cell transplantation (PSCT). However, PSCT has several potential advantages in patients with BMF, including higher stem cell doses to prevent graft failure and faster rates of engraftment. We present a retrospective analysis of patients (pts) with BMF who received PSCT with partial T cell depletion (pTCD) using a strategy of CD3/CD19 depletion with targeted T cell add-back, chosen to balance the risk of GvHD seen with T cell replete PSCT with the risks of graft failure and viral infections seen with full T cell depletion.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2015.11.693

Authors: Mala Kiran Talekar, Yongping Wang, Dimitri S. Monos, Stephan A. Grupp, Nancy J. Bunin, Timothy S. Olson

Institution: Children's Hospital of Philadelphia

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650