Work

Cell‐Aligning Substrates: Anisotropically Stiff 3D Micropillar Niche Induces Extraordinary Cell Alignment and Elongation (Adv. Healthcare Mater. 15/2016)

Year: 2016

Type: article

Abstract: On Page 1884, Y. Alapan, M. Younesi, O. Akkus, and U. A. Gurkan demonstrate a microfabricated pillar substrate to confine, align, and elongate cells for decoupled analysis of stiffness and directionality in 3D. Mesenchymal stem cells and cardiomyocytes are successfully confined in a 3D micromechanical environment with precisely tunable stiffness anisotropy. Cell alignment in the stiffer direction and extraordinary elongation is discovered with 3D cellular confinement in anisotropically stiff micropillar substrates.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.201670075

Authors: Yunus Alapan, Mousa Younesi, Ozan Akkus, Umut A. Gurkan

Institutions: Case Western Reserve University, Louis Stokes Cleveland VA Medical Center

Language: English

Topic: Cellular Mechanics and Interactions

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2509374582

FWCI: 0.917

Cites:

Cited by: 5

Related to: 10