Work

Ratiometric analysis of in vivo retinal layer thicknesses in multiple sclerosis

Year: 2016

Type: article

Abstract: We performed ratiometric analysis of retinal optical coherence tomography images for the first time in multiple sclerosis (MS) patients. The ratiometric analysis identified differences in several retinal layer thickness ratios in the cohort of MS subjects without a history of optic neuritis (ON) compared to healthy control (HC) subjects, and there was no difference in standard retinal nerve fiber layer thickness (RNFLT). The difference in such ratios between HC subjects and those with mild MS-disability, without a difference in RNFLT, further suggests the possibility of using layer ratiometric analysis for detecting early retinal changes in MS. Ratiometric analysis may be useful and potentially more sensitive for detecting disease changes in MS.

Source: Journal of Biomedical Optics

DOI: 10.1117/1.jbo.21.9.095001

Authors: Basanta Bhaduri, Ryan M. Nolan, Ryan L. Shelton, Lara A. Pilutti, Robert W. Motl, Stephen A. Boppart

Institutions: University of Illinois Urbana-Champaign, Indian Institute of Technology Dhanbad, University of Alabama at Birmingham

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: University of Pittsburgh, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign