Work

Rapid Expansion of Tumor-Specific T Cells Using Nanoparticle-Based Artificial Antigen Presenting Cells (aAPCs)

Year: 2016

Type: article

Abstract: Adoptive cell transfer (ACT) of tumor-specific T cells for the treatment of cancer has been used to mediate durable responses in multiple malignancies. However, despite its significant therapeutic potential, the routine use of ACT has been limited. This has been due, in large part, to the high cost, intricate and labor-intensive methods required to successfully generate autologous antigen-specific T cells. Here, we report on the application of a recently described novel nanoparticle-based method for expansion of tumor-specific T cells from normal human donors.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2015.11.490

Authors: Juan Carlos Varela, Christian Schuetz, Mathias Oelke, Jonathan Schneck

Institutions: Medical University of South Carolina, Paul Ehrlich Institut, NexImmune (United States), Johns Hopkins University

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650