Work

Drug-drug Interaction Profiles of Medication Regimens Extracted From a De-identified Electronic Medical Records System.

Year: 2016

Type: article

Abstract: With age, the number of prescribed medications increases and subsequently raises the risk for adverse drug-drug interactions. These adverse effects lower quality of life and increase health care costs. Quantifying the potential burden of adverse effects before prescribing medications can be a valuable contribution to health care. This study evaluated medication lists extracted from a subset of the Vanderbilt de-identified electronic medical record system. Reported drugs were cross-referenced with the Kyoto Encyclopedia of Genes and Genomes DRUG database to identify known drug-drug interactions. On average, a medication regimen contained 6.58 medications and 2.68 drug-drug interactions. Here, we quantify the burden of potential adverse events from drug-drug interactions through drug-drug interaction profiles and include a number of alternative medications as provided by the Anatomical Therapeutic Chemical Classification System.

Source: PubMed

Authors: Mariusz Butkiewicz, Nicole A Restrepo, Jonathan L Haines, Dana C Crawford

Institution: Case Western Reserve University

Language: English

Topic: Pharmaceutical Practices and Patient Outcomes

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Human Genome Research Institute, National Center for Research Resources

Awards: The Vanderbilt Institute for Clinical and Translational Research (VICTR) UL1, The Vanderbilt Institute for Clinical and Translational Research (VICTR), Epidemiologic Architecture for Genes Linked to Environment (EAGLE)