Year: 2016
Type: article
Abstract: Autism spectrum disorder (ASD) is a developmental disorder diagnosed behaviorally, with many documented neurophysiological abnormalities in cortical response properties. While abnormal sensory processing is not considered core to the disorder, most ASD individuals report sensory processing abnormalities. Yet, the neurophysiological correlates of these abnormalities have not been fully mapped. In the auditory domain, studies have shown that cortical responses in the early auditory cortex in ASD are abnormal in multiple ways. In particular, it has been shown that individuals with ASD have abnormal cortical auditory evoked responses to rapid, but not slow, sequences of tones. In parallel, there is substantial evidence of somatosensory processing abnormalities in ASD, including in the temporal domain. Here, we tested the somatosensory domain in ASD for abnormalities in rapid processing of tactile pulses, to determine whether abnormalities there parallel those observed in the auditory domain. Specifically, we tested the somatosensory cortex response to a sequence of two tactile pulses with different (short and long) temporal separation. We analyzed the responses in cortical space, in primary somatosensory cortex. As expected, we found no group difference in the evoked response to pulses with long (700 ms) temporal separation. Contrary to findings in the auditory domain, we also found no group differences in the evoked responses to the sequence with a short (200 ms) temporal separation. These results suggest that rapid temporal processing deficits in ASD are not generalized across multiple sensory domains, and are unlikely to underlie the behavioral somatosensory abnormalities observed in ASD.
Source: Frontiers in Human Neuroscience
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funders: National Science Foundation, Autism Speaks, Simons Foundation, Nancy Lurie Marks Family Foundation, Simons Foundation Autism Research Initiative, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1184130088, Cognitive Rhythms Collaborative: A Discovery Network, G336617548, Tools for Large-Scale Platform-Independent MEG Data Analysis, G4086383602, G590890658, Functional connectivity substrates of social and non-social deficits in ASD, G6678428488, Center for Functional Imaging Technologies
OpenAlex ID: W2510320015