Year: 2016
Type: article
Abstract: Organizers are regions of the embryo that can both induce new fates and impart pattern on other regions. So far, surprisingly few organizers have been discovered, considering the number of patterned tissue types generated during development. This may be because their discovery has relied on transplantation and ablation experiments. Here we describe a new approach, using chick embryos, to discover organizers based on a common gene expression signature, and use it to uncover the anterior intestinal portal (AIP) endoderm as a putative heart organizer. We show that the AIP can induce cardiac identity from non-cardiac mesoderm and that it can pattern this by specifying ventricular and suppressing atrial regional identity. We also uncover some of the signals responsible. The method holds promise as a tool to discover other novel organizers acting during development.
Source: Nature Communications
DOI: 10.1038/ncomms12656
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,735
Awards: G1252325381, A three-dimensional atlas of gene expression during chick development with cross comparisons to the mouse, Transcriptomes, networks and systems, Modelling Cellular and Tissue Systems, A three-dimensional atlas of gene expression during chick development with cross comparisons to the mouse, Increase understanding tissue development to improve production and health, A three-dimensional atlas of gene expression during chick development with cross comparisons to the mouse
OpenAlex ID: W2510488331