Year: 2016
Type: article
Abstract: Proton magnetic resonance imaging (1H MRI) of gases can potentially enable functional lung imaging to probe gas ventilation and other functions. Here, 1H MR images of hyperpolarized (HP) and thermally polarized propane gas were obtained using ultrashort echo time (UTE) pulse sequence. A 2-dimensional (2D) image of thermally polarized propane gas with ∼0.9 × 0.9 mm2 spatial resolution was obtained in <2 seconds, showing that even non-HP hydrocarbon gases can be successfully used for conventional proton magnetic resonance imaging. The experiments were also performed with HP propane gas, and high-resolution multislice FLASH 2D images in ∼510 seconds and non-slice-selective 2D UTE MRI images were acquired in ∼2 seconds. The UTE approach adopted in this study can be potentially used for medical lung imaging. Furthermore, the possibility of combining UTE with selective suppression of 1H signals from 1 of the 2 gases in a mixture is shown in this MRI study. The latter can be useful for visualizing industrially important processes where several gases may be present, eg, gas–solid catalytic reactions.
Source: Tomography
Language: English
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,896
Funders: National Science Foundation, U.S. Department of Defense, Exxon Mobil Corporation, Russian Foundation for Basic Research, Siberian Branch, Russian Academy of Sciences, National Institutes of Health, Council on grants of the President of the Russian Federation, National Institute of Biomedical Imaging and Bioengineering, Division of Chemistry, Congressionally Directed Medical Research Programs
Awards: International Collaboration in Chemistry: Collaborative Research: Development of Novel Catalysts and Approaches for Parahydrogen-Induced Enhancement of Magnetic Resonance, Screening and Monitoring Response to Treatment Using Subsecond Molecular Imaging and Hyperpolarized Contrast Agents, G196227769, International Collaboration in Chemistry: Collaborative Research: Development of Novel Catalysts and Approaches for Parahydrogen-Induced Enhancement of Magnetic Resonance, G2064820846, G2160632998, G2164975495, LOW-COST, HIGH-THROUGHPUT 3D PULMONARY IMAGER USING HYPERPOLARIZED CONTRAST AGENTS AND LOW-FIELD MRI, G2533466730, G2800195642, G2953707141, G334857593, G4034588369, G4058302672, G4119534169, G4138142980, G4455908853, G4955926212, G5324093878, G5850682332, Low-Cost, High-Throughput 3D Pulmonary Imager Using Hyperpolarized Contrast Agents and Low-Field MRI, G6948885953, G7147166237, SCREENING AND MONITORING RESPONSE TO TREATMENT USING SUBSECOND MOLECULAR IMAGING AND HYPERPOLARIZED CONTRAST AGENTS, G9000073449, G9000184693
OpenAlex ID: W2510567329