Nonsteroidal Anti-Inflammatory Drug Use is Not Associated With Reduced Risk of Barrett’s Esophagus
Year: 2016
Type: article
Abstract: OBJECTIVES: Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced risk of esophageal adenocarcinoma. Epidemiological studies examining the association between NSAID use and the risk of the precursor lesion, Barrett's esophagus, have been inconclusive. METHODS: We analyzed pooled individual-level participant data from six case-control studies of Barrett's esophagus in the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON). We compared medication use from 1,474 patients with Barrett's esophagus separately with two control groups: 2,256 population-based controls and 2,018 gastroesophageal reflux disease (GERD) controls. Study-specific odds ratio (OR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression models and were combined using a random-effects meta-analytic model. RESULTS: =19%). Similar null findings were observed among individuals who took aspirin or non-aspirin NSAIDs. We also found no association with highest levels of frequency (at least daily use) and duration (≥5 years) of NSAID use. There was evidence of moderate between-study heterogeneity; however, associations with NSAID use remained non-significant in "leave-one-out" sensitivity analyses. CONCLUSIONS: Use of NSAIDs was not associated with the risk of Barrett's esophagus. The previously reported inverse association between NSAID use and esophageal adenocarcinoma may be through reducing the risk of neoplastic progression in patients with Barrett's esophagus.
DOI: 10.1038/ajg.2016.348
Institutions: Baylor College of Medicine, Dan L Duncan Comprehensive Cancer Center, Queen's University Belfast, National Cancer Institute, Division of Cancer Epidemiology and Genetics, University of North Carolina at Chapel Hill, University of Michigan, Michigan Medicine, VA Center for Clinical Management Research, Ann Arbor VA Medical Center, Michael E. DeBakey VA Medical Center, Fred Hutch Cancer Center, Kaiser Permanente, Kaiser Permanente San Francisco Medical Center, QIMR Berghofer Medical Research Institute
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Epidemiologic Case-control Study of Barrett's Esophagus, The Epidemiology of Adipokines in Barrett's Esophagus, Molecular epidemiology of Barretts esophagus and cancer, Epidemiology and Outcomes of Digestive and Liver Diseases: A Mentoring Program, G2937657777, EPIDEMIOLOGY OF BARRETTS ESOPHAGUS, Epidemiology and Incidence of Barrett's Esophagus, The Perception of Cancer Risk in Patients with Barrett's Esophagus, Obesity, H pylori and Risk of Barrett's Esophagus, ESTABLISHED INVESTIGATOR AWARD IN CANCER PREVENTION AND CONTROL, Barrett's Esophagus: Risk Factors in Women, Texas Medical Center Digestive Diseases Center, Barrett's Esophagus
OpenAlex ID: W2511442435