Work

Role of ginsenosides, the main active components of Panax ginseng , in inflammatory responses and diseases

Year: 2016

Type: review

Abstract: is one of the most universally used herbal medicines in Asian and Western countries. Most of the biological activities of ginseng are derived from its main constituents, ginsenosides. Interestingly, a number of studies have reported that ginsenosides and their metabolites/derivatives-including ginsenoside (G)-Rb1, compound K, G-Rb2, G-Rd, G-Re, G-Rg1, G-Rg3, G-Rg5, G-Rh1, G-Rh2, and G-Rp1-exert anti-inflammatory activities in inflammatory responses by suppressing the production of proinflammatory cytokines and regulating the activities of inflammatory signaling pathways, such as nuclear factor-κB and activator protein-1. This review discusses recent studies regarding molecular mechanisms by which ginsenosides play critical roles in inflammatory responses and diseases, and provides evidence showing their potential to prevent and treat inflammatory diseases.

Source: Journal of Ginseng Research

DOI: 10.1016/j.jgr.2016.08.004

Authors: Ji Hye Kim, Young-Su Yi, Mi-Yeon Kim, Jae Youl Cho

Institutions: Sungkyunkwan University, Cheongju University, Soongsil University

Language: English

Topic: Ginseng Biological Effects and Applications

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Korea Ginseng Corporation