Insufficient Evidence for Rare Activation of Latent HIV in the Absence of Reservoir-Reducing Interventions
Year: 2016
Type: article
Abstract: A priority for HIV cure research is measuring latent infection that can fuel viral recrudescence if patients cease antiretroviral therapy (ART). One important quantity that is difficult to measure is the rate at which latently infected cells activate, giving rise to spreading infection [1]. Pinkevych et al. recently estimated this rate by analyzing several clinical cohorts and concluded that one cell activates every 6 days [2]. This rate is 24-fold lower than our previous estimate of 4 cells/day [1], resulting in far more optimistic predictions for the prospects of reservoir-reducing therapy. We question their estimation approach and suggest that a higher rate is likely for most infected individuals.
Source: PLoS Pathogens
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,043
Funders: Bill and Melinda Gates Foundation, Harvard University, Harvard University Center for AIDS Research, Johns Hopkins University, National Institutes of Health, Center for AIDS Research, University of Washington, Center for AIDS Research, Johns Hopkins University, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, U.S. National Library of Medicine
Awards: Quantification and prediction of treatment efficacy for HIV cure strategies, G1575283533, Uncovering Evolutionary History using the Topology of Genomic Data with Applications to HIV, G2349735882, G2483435703, DARE: Delaney AIDS Research Enterprise to find a cure., Latent Viral Reservoirs in HIV 1 Infection, G345173699, G4060295378, G653582874, G7178514535, G720459795, Martin Delaney Collaboratory to Eradicate HIV-1 Infection, G9000070645, The Johns Hopkins Center for AIDS Research (JHU CFAR), Training in Biomedical Informatics at Columbia University, Harvard University Center for AIDS Research
OpenAlex ID: W2511684248