Work

Jumping Translocations in Myelodysplastic Syndromes

Year: 2016

Type: article

Abstract: Jumping translocations (JTs) have been described infrequently in myelodysplastic syndromes (MDS), with less than 10 cases in the literature. Although JT have mapped most commonly to 1q, breakpoints involving other chromosomal loci, such as 11q and 3q, have also been described. MDS represent a heterogeneous group of diseases with ineffective hematopoiesis and varied clinical prognosis including a subset of high risk cases which progress to leukemia. Identification of these cases warrants more aggressive therapy early in the course, including hematopoietic cell transplantation (HCT).

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2015.11.612

Authors: Cecilia Yeung, H. Joachim Deeg, Colin Pritchard, David Wu, Min Fang

Institutions: Fred Hutch Cancer Center, University of Washington

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650