Work

Efficacy and Safety of Defibrotide in a Subset Analysis of Late-Onset Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome (VOD/SOS) Patients from an Ongoing, Expanded-Access Program

Year: 2016

Type: article

Abstract: Hepatic VOD/SOS is a potentially life-threatening complication of conditioning regimens for hematopoietic stem cell transplant (HSCT). Severe VOD/SOS, often defined as VOD/SOS and multi-organ dysfunction (MOD), may be associated with >80% mortality. Although VOD/SOS onset typically occurs <20 or 21 days post-HSCT (per diagnostic criteria), there have been reported cases of later-onset VOD/SOS (up to Day+50 [Carreras E. Br J Haematol. 2015;168:481-91]). Also, late-onset VOD/SOS may be diagnosed after hospital discharge, potentially delaying treatment.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2015.11.768