Risk of Lung Disease in PI MZ Heterozygotes. Current Status and Future Research Directions
Year: 2016
Type: article
Abstract: The potential for increased chronic obstructive pulmonary disease (COPD) risk among PI MZ subjects was initially recognized decades ago. However, despite many studies of this topic, it has remained controversial whether such increased risk exists. Several recent studies in large populations strongly support increased risk for COPD among PI MZ subjects. This increased PI MZ risk will need to be understood in the context of other identified COPD genetic determinants and investigations of COPD phenotypic heterogeneity.
Author: Edwin K. Silverman
Institutions: Brigham and Women's Hospital, Harvard University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1410957586, Identifying Genetic Determinants of Severe, Early-Onset COPD, (2 of 2) Genetic Epidemiology of COPD, Functional Genetics of COPD, (1 of 2) Genetic Epidemiology of COPD, (2 of 2) Genetic Epidemiology of COPD, (1 of 2) Genetic Epidemiology of COPD, Using Networks to Assign Gene Function in Lung Disease, Distinct and Overlapping Pathways of Fibrosis and Emphysema in Cigarette Smokers
OpenAlex ID: W2512932385