Prenatal unhealthy diet, insulin‐like growth factor 2 gene ( IGF 2 ) methylation, and attention deficit hyperactivity disorder symptoms in youth with early‐onset conduct problems
Year: 2016
Type: article
Abstract: BACKGROUND: Conduct problems (CP) and attention deficit hyperactivity disorder (ADHD) are often comorbid and have each been linked to 'unhealthy diet'. Early-life diet also associates with DNA methylation of the insulin-like growth factor 2 gene (IGF2), involved in fetal and neural development. We investigated the degree to which prenatal high-fat and -sugar diet might relate to ADHD symptoms via IGF2 DNA methylation for early-onset persistent (EOP) versus low CP youth. METHODS: Participants were 164 youth with EOP (n = 83) versus low (n = 81) CP drawn from the Avon Longitudinal Study of Parents and Children. We assessed if the interrelationships between high-fat and -sugar diet (prenatal, postnatal), IGF2 methylation (birth and age 7, collected from blood), and ADHD symptoms (age 7-13) differed for EOP versus low CP youth. RESULTS: Prenatal 'unhealthy diet' was positively associated with IGF2 methylation at birth for both the EOP and low CP youth. For EOP only: (a) higher IGF2 methylation predicted ADHD symptoms; and (b) prenatal 'unhealthy diet' was associated with higher ADHD symptoms indirectly via higher IGF2 methylation. CONCLUSIONS: Preventing 'unhealthy diet' in pregnancy might reduce the risk of ADHD symptoms in EOP youth via lower offspring IGF2 methylation.
DOI: 10.1111/jcpp.12589
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,002
Funders: Wellcome Trust, University of Bristol, Medical Research Council, Biotechnology and Biological Sciences Research Council, Economic and Social Research Council, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1192034430, G1415860003, G1605161196, The Adaptation and Initial Evaluation of an Intervention to Promote Mental Health Outcome of Adolescents Living With HIV in Rural Kenya, G1955001954, G235045266, How early stress gets under the skin: The role of DNA methylation in the development of youth conduct problems and comorbid symptoms, G317400622, G3233603352, G3831911591, Accessible resource for integrated epigenomics studies (ARIES), The Avon Longitudinal Study for Parents and Children: An international resource for population genomic and lifecourse epidemiology. Core programme support 2014-2019., The Avon Longitudinal Study of Parents and Children: An international resource for population
genomics and lifecourse epidemiology. Core Programme Support 2011-2015 and Core programme support 2014-2019, G5562631338, Accessible resource for integrated epigenomics studies (ARIES), G6119919417, G6751436026, G738105237, G7614373100, G7775523268, Epigenetic Pathways to Conduct Problem Trajectories: Early Environmental Risks, G824700880, G8459925867
OpenAlex ID: W2513373784